Hematology and Oncology Research
Divisional Clinical Research Office
We are committed to clinical research and scholarship that transforms the landscape of pediatric hematology and oncology. About our research:
- 30 open therapeutic studies
- Children鈥檚 Oncology Group (COG), Beat Childhood Cancer, Sunshine Kids
- 12 non-therapeutic open clinical studies
- 5 investigator-initiated studies
- We are in the top 20% of all COG institutions for enrollments on therapeutic clinical trials
Investigational Research
- Characterization of TP53 mutations
- Variants of uncertain significance in cancer genes
- Pharmacogenomic variants - medication toxicity
- Germline and neuro-oncology molecular tumor boards
- Calcitonin gene-related peptide in NF1
- Biobank repository at the Markey Cancer Center
- ATM heterozygosity - therapeutic toxicity
- Incidence of ped CNS tumors in KY
- Exercise intervention in PHO clinic
- Psychosocial aspects of inherited cancer
- Financial toxicity of pediatric cancer
- Clinical trial enrollments - COG, others
- Zebrafish avatars - DIPG
- Hemophilia projects
- Collaboration with Norton Children's Hospital
- Circulating tumor DNA - leukemia
- PAR4 tumor suppressor - Wilm's tumor
- Project Inherited Cancer Risk